منابع مشابه
Neurotoxic Mechanisms of Methylmercury: Cellular and Behavior Changes
Neurotoxic Mechanisms of Methylmercury: Cellular and Behavior Changes.
متن کاملDifferential neurotoxic effects of methylmercury and mercuric sulfide in rats.
Methylmercury (MeHg) is an environmental toxicant, while mercuric sulfide (HgS) is a main active component of cinnabar, a Chinese mineral medicine used as a sedative. Because the neurotoxicological effects of HgS were not clearly understood, in this study, we attempted to compare HgS with MeHg in various physiological responses in Sprague-Dawley rats. After oral administration (2 mg/(kg day)) f...
متن کاملMechanisms of methylmercury-induced neurotoxicity.
Mercury in both organic and inorganic forms is neurotoxic. Methylmercury (MeHg) is a commonly encountered form of mercury in the environment. Early electrophysiological experiments revealed that MeHg potently affects the release of neurotransmitter from presynaptic nerve terminals. Recently, the hypothesis that these alterations may be mediated by changes in the intracellular concentration of C...
متن کاملC-terminal fragments of APP: Its neurotoxic mechanisms and involvement in gene transcription
Several lines of evidence suggest that some neurotoxicity in AD is due to proteolytic fragments of APP. In this study, we compared the potency of neurotoxicity induced by CT with that of A-beta neurotoxicity and our results showed that various CT peptide fragments (CTFs; CTF99, AICD, CTF31) caused neurotoxicity in cultured cells and primary cortical neurons, induced strong non-selective inward ...
متن کاملC-terminal fragments of APP: Its neurotoxic mechanisms and involvement in gene transcription
Several lines of evidence suggest that some neurotoxicity in AD is due to proteolytic fragments of APP. In this study, we compared the potency of neurotoxicity induced by CT with that of A-beta neurotoxicity and our results showed that various CT peptide fragments (CTFs; CTF99, AICD, CTF31) caused neurotoxicity in cultured cells and primary cortical neurons, induced strong non-selective inward ...
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ژورنال
عنوان ژورنال: Eisei kagaku
سال: 1998
ISSN: 0013-273X
DOI: 10.1248/jhs1956.44.393